Sodium Hydroxide → HCID 178433901、化合物

HRID 497949ノート

反応式

HRID 497949 の反応式
[OH:1][C:2]1[C:7]([C:8]([O:10]CC)=[O:9])=[CH:6][N:5]=[C:4]2[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[N:14]=[C:15]([CH3:16])[C:3]=12.[OH-].[Na+]>Cl>[OH:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=[C:4]2[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[N:14]=[C:15]([CH3:16])[C:3]=12

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 178469580HCID 178469580、化合物

生成物 1

HCID 178433901HCID 178433901、化合物収率 33.1%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

反応条件

温度
100 °C

実験手順

A suspension of ethyl 4-hydroxy-3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (2.0 g, 6.7 mmol) in 6N hydrochloric acid solution (10 mL) was heated and stirred at 100° C. for 1 hour. The solution was cooled to room temperature, made weakly acidic by the addition of an aqueous sodium hydroxide solution, and the resulting precipitate was collected by filtration. The crude crystals thus obtained were washed with water and dried to give the title compound (0.6 g, 33% yield).

後処理

  1. temperaturewas heated
  2. temperatureThe solution was cooled to room temperature
  3. filtrationthe resulting precipitate was collected by filtration
  4. customThe crude crystals thus obtained
  5. washwere washed with water
  6. customdried

出典と根拠

ORDレコード
ord-99b1e2b8f93c4d12ade94fe950e238e3
出典データセット
uspto-grants-2005_09
特許番号
US06949648B2

反応ノート

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