Hydrochloric Acid → N-(2-fluorophenyl)-2-(hydroxyimino)acetamide

HRID 497986

反応式

HRID 497986 の反応式
Cl[C:2](Cl)(Cl)[CH:3]([OH:5])O.S([O-])([O-])(=O)=O.[Na+].[Na+].[F:15][C:16]1[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=1[NH2:18].Cl.Cl.[NH2:25][OH:26]>O>[F:15][C:16]1[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=1[NH:18][C:3](=[O:5])[CH:2]=[N:25][OH:26]

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 2707Chloral HydrateHCID 95842-FluoroanilineHCID 24436Sodium SulfateHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 6710880N-(2-fluorophenyl)-2-(hydroxyimino)acetamide収率 86%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

The title compound was prepared according to the method described in J. Heterocyclic Chem., vol. 27, p. 2151 (1990). To a solution of chloral hydrate (44.2 g, 267 mmol) and sodium sulfate (304 g, 2.14 mol) in water (700 mL), was added a solution of 2-fluoroaniline (27.0 g, 243 mmol) and conc. hydrochloric acid (70 mL) in water (140 mL) dropwise at room temperature, and furthermore hydroxylamine hydrochloride (74.4 g, 1.07 mol), and the resulting solution was heated under reflux for 10 minutes. The solution was ice cooled and the resulting crystals were collected by filtration and air dried to give the title compound (38.0 g, 86% yield).

後処理

  1. customThe title compound was prepared
  2. temperatureunder reflux for 10 minutes
  3. temperaturecooled
  4. filtrationthe resulting crystals were collected by filtration and air
  5. customdried

出典と根拠

ORDレコード
ord-bc77d98539d54525af175b434f6f2e5a
出典データセット
uspto-grants-2005_09
特許番号
US06949648B2

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