Water → 4-[N-(tert-butyl)-N-hydroxyamino]-N-(8-hydroxyquinolin-5-yl)-benzamide
反応式
[C:1]([N:5]([C:14]1[CH:33]=[CH:32][C:17]([C:18]([NH:20][C:21]2[CH:30]=[CH:29][C:28]([OH:31])=[C:27]3[C:22]=2[CH:23]=[CH:24][CH:25]=[N:26]3)=[O:19])=[CH:16][CH:15]=1)[O:6][Si](C(C)(C)C)(C)C)([CH3:4])([CH3:3])[CH3:2].[F-].C([N+](CCCC)(CCCC)CCCC)CCC.O.[NH4+].[Cl-]>C1COCC1.C(OCC)(=O)C>[C:1]([N:5]([C:14]1[CH:33]=[CH:32][C:17]([C:18]([NH:20][C:21]2[CH:30]=[CH:29][C:28]([OH:31])=[C:27]3[C:22]=2[CH:23]=[CH:24][CH:25]=[N:26]3)=[O:19])=[CH:16][CH:15]=1)[OH:6])([CH3:4])([CH3:2])[CH3:3]参加物
7
反応物 4
生成物 1
試薬・触媒・溶媒 2
実験手順
To a solution of 0.04 g (0.085 mmol) of compound 9 in THF (1 mL) was added 0.43 mL (0.43 mmol) of 1 M solution of tetrabutylammonium fluoride in THF at room temperature, and the solution was stirred for 1 hour. After completion of the reaction, 2 mL of water was added to quench the reaction. Ethyl acetate and sat'd NH4Cl solution were added to the mixture. The organic layer was separated, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was purified by flash column chromatography (silica, Hex:EtOAc=10:1) to give 0.021 g of compound 10 in 70% yield.
後処理
- additionwas added
- customto quench
- customthe reaction
- additionwere added to the mixture
- customThe organic layer was separated
- dry with materialdried over anhydrous MgSO4
- filtrationfiltered
- concentrationconcentrated under reduced pressure
- customThe residue was purified by flash column chromatography (silica, Hex:EtOAc=10:1)
出典と根拠
- ORDレコード
- ord-b56c13ee9d884a7aa4b70111b35216e5
- 出典データセット
- uspto-grants-2005_09
- 特許番号
- US06949654B2
反応ノート
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