Hydrochloric Acid → 5-Oxo-5-phenylpentyl 3-cyclohexylpropionate

HRID 498143ノート

反応式

HRID 498143 の反応式
Cl.[CH:2]1([CH2:8][CH2:9][C:10]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]2([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)OCC[O:18]2)=[O:11])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.CCCCCCC.CCOCC>C1COCC1>[CH:2]1([CH2:8][CH2:9][C:10]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17](=[O:18])[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[O:11])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 21897273Diethylether heptaneHCID 223209114-(2-Phenyl-1,3-dioxolan-2-yl)butyl 3-cyclohexylpropionate

生成物 1

HCID 233934765-Oxo-5-phenylpentyl 3-cyclohexylpropionate収率 60%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

This compound was synthesised as described under 1.e) with 2.0 ml of a 1N solution of HCl, 4.12 g (11.4 mmol) of 4-(2-phenyl-1,3-dioxolan-2-yl)butyl 3-cyclohexylpropionate obtained under a) in 20 ml of THF for 19 h. Column chromatography (SiO2, heptane/ether 3:2) afforded 2.15 g (60%) of a yellow oil containing small amounts of impurities, which can be distilled off (Kugelrohr, 150° C./1×102 Pa).

後処理

  1. customThis compound was synthesised

出典と根拠

ORDレコード
ord-08989cca380649908deadf9dd7642df1
出典データセット
uspto-grants-2005_09
特許番号
US06949680B2

反応ノート

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