Boc-Leu-Ala-OBzl → H-Leu-Ala-OBzl

HRID 4982

反応式

HRID 4982 の反応式
[NH:1]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C@H:2]([C:7]([NH:9][C@H:10]([C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])[CH3:11])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5]>FC(F)(F)C(O)=O>[NH:1]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C@H:2]([C:7]([NH:9][C@H:10]([C:12]([O:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:13])[CH3:11])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:12]([O:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:13])[CH3:11])=[O:8])[CH2:3][CH:4]([CH3:5])[CH3:6]

参加物

4

反応物 1

HCID 58901353Boc-Leu-Ala-OBzl

生成物 2

HCID 16742166H-Leu-Ala-OBzlHCID 58901353Boc-Leu-Ala-OBzl

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

Boc-Leu-Ala-OBzl was prepared by the procedure for dipeptide synthesis in Example 2. Boc-Leu-Ala-OBzl (23.7 g, 57.7 mmoles) was dissolved in 40 mL of anhydrous trifluoroacetic acid. After 15 min, excess trifluoroacetic acid was removed by evaporation and the residue was treated with ether to yield H-Leu-Ala-OBzl.trifluoroacetic acid as a crystalline product (22.8 g).

後処理

  1. customexcess trifluoroacetic acid was removed by evaporation
  2. additionthe residue was treated with ether

出典と根拠

ORDレコード
ord-d330762a78a24610a29680bec14ad834
出典データセット
uspto-grants-1993_09
特許番号
US05242904

関連ノート

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