(4-Methyl-2-nitro-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester → (2-Amino-4-methyl-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

HRID 498210

反応式

HRID 498210 の反応式
[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[C:11]([CH3:18])=[CH:10][C:9]=1[N+:19]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[C:11]([CH3:18])=[CH:10][C:9]=1[NH2:19])([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 1

HCID 69486805(4-Methyl-2-nitro-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

生成物 1

HCID 69489396(2-Amino-4-methyl-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester収率 87%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

Prepared from (4-methyl-2-nitro-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example A18) (4.68 g, 14.6 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a white solid (3.68 g, 87%).

出典と根拠

ORDレコード
ord-43be8b0323224b32b648ee39f67ac3ca
出典データセット
uspto-grants-2005_09
特許番号
US06949542B2

関連ノート

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