Water → 4-(Morpholin-4-yl)benzoic acid

HRID 49831

反応式

HRID 49831 の反応式
[N:1]1([C:7]2[CH:14]=[CH:13][C:10]([C:11]#N)=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O1CCOCC1.[OH-:21].[K+].[OH2:23]>>[N:1]1([C:7]2[CH:14]=[CH:13][C:10]([C:11]([OH:23])=[O:21])=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

参加物

5

反応物 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 312751,4-DioxaneHCID 3948084-Morpholinobenzonitrile

生成物 1

HCID 3452784-(Morpholin-4-yl)benzoic acid収率 99%

実験手順

A solution of 4-(4-morpholinyl)benzonitrile (930 mg, 5.00 mmol) in 1:1 dioxane:water (20 mL) was treated with potassium hydroxide (1.12 g, 20 mmol). The mixture was heated at reflux for 96 h, concentrated, and the residue was dissolved in water. Upon acidification (pH ˜2-3), a white precipitate resulted which was collected by filtration yielding 1.21 g (99%) of the title compound.

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 96 h
  3. concentrationconcentrated
  4. dissolutionthe residue was dissolved in water
  5. customUpon acidification (pH ˜2-3), a white precipitate resulted which
  6. filtrationwas collected by filtration

出典と根拠

ORDレコード
ord-7ad0d7d1880144fa87a13458aa991f81
出典データセット
uspto-grants-2004_03
特許番号
US06710057B2

関連ノート

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