Trifluoroacetic acid → 8-Methyl-4-(3-pyrazin-2-yl-phenyl)-7-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 498587ノート

反応式

HRID 498587 の反応式
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12](C(F)(F)F)[C:11](C)=[CH:10][C:9]=1[NH:19][C:20](=[O:36])[CH2:21][C:22](=O)[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]2[CH:34]=[N:33][CH:32]=[CH:31][N:30]=2)[CH:24]=1)(C)(C)C.[C:38](O)([C:40]([F:43])([F:42])[F:41])=O>C(Cl)Cl>[CH3:12][C:11]1[C:38]([C:40]([F:43])([F:42])[F:41])=[CH:13][C:8]2[N:7]=[C:22]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([C:29]4[CH:34]=[N:33][CH:32]=[CH:31][N:30]=4)[CH:24]=3)[CH2:21][C:20](=[O:36])[NH:19][C:9]=2[CH:10]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86589286{4-Methyl-2-[3-oxo-3-(3-pyrazin-2-yl-phenyl)-propionylamino]-5-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester

生成物 1

HCID 223179338-Methyl-4-(3-pyrazin-2-yl-phenyl)-7-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The title compound was prepared from {4-methyl-2-[3-oxo-3-(3-pyrazin-2-yl-phenyl)-propionylamino]-5-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (Example M85) (0.28 g, 0.54 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (146 mg, 68%).

出典と根拠

ORDレコード
ord-d15cc46ab35c43feb4b1861c9ca1e085
出典データセット
uspto-grants-2005_09
特許番号
US06949542B2

反応ノート

読み込み中…