Trifluoroacetic acid → 7-(Methyl-propyl-amino)-4-(3-pyrimidin-5-yl-phenyl)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 498593ノート

反応式

HRID 498593 の反応式
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:18])[CH2:15][CH2:16][CH3:17])[C:11]([C:19]([F:22])([F:21])[F:20])=[CH:10][C:9]=1[NH:23][C:24](=[O:40])[CH2:25][C:26](=O)[C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]2[CH:34]=[N:35][CH:36]=[N:37][CH:38]=2)[CH:28]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:18][N:14]([CH2:15][CH2:16][CH3:17])[C:12]1[C:11]([C:19]([F:22])([F:20])[F:21])=[CH:10][C:9]2[NH:23][C:24](=[O:40])[CH2:25][C:26]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([C:33]4[CH:38]=[N:37][CH:36]=[N:35][CH:34]=4)[CH:28]=3)=[N:7][C:8]=2[CH:13]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86589291{5-(Methyl-propyl-amino)-2-[3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester

生成物 1

HCID 223174897-(Methyl-propyl-amino)-4-(3-pyrimidin-5-yl-phenyl)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The title compound was prepared from {5-(methyl-propyl-amino)-2-[3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (Example M90) (0.40 g, 0.70 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light orange solid (210 mg, 66%).

出典と根拠

ORDレコード
ord-57eb6ccfe05b4bcea91fe54cb1054c15
出典データセット
uspto-grants-2005_09
特許番号
US06949542B2

反応ノート

読み込み中…