Trifluoroacetic acid → 8-Chloro-4-[3-(6-ethyl-pyridin-3-yl)-phenyl]-7-methyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 498668ノート

反応式

HRID 498668 の反応式
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([Cl:15])=[CH:10][C:9]=1[NH:16][C:17](=[O:35])[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([C:27]2[CH:28]=[N:29][C:30]([CH2:33][CH3:34])=[CH:31][CH:32]=2)[CH:22]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:15][C:11]1[C:12]([CH3:14])=[CH:13][C:8]2[N:7]=[C:19]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([C:27]4[CH:28]=[N:29][C:30]([CH2:33][CH3:34])=[CH:31][CH:32]=4)[CH:22]=3)[CH2:18][C:17](=[O:35])[NH:16][C:9]=2[CH:10]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86589355(4-Chloro-2-{3-[3-(6-ethyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-5-methyl-phenyl)-carbamic acid tert-butyl ester

生成物 1

HCID 223173588-Chloro-4-[3-(6-ethyl-pyridin-3-yl)-phenyl]-7-methyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The title compound was prepared from (4-chloro-2-{3-[3-(6-ethyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-5-methyl-phenyl)-carbamic acid tert-butyl ester (Example M171) (290 mg, 0.57 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (145 mg, 65%).

出典と根拠

ORDレコード
ord-1f67ec86055341f9acab06f2be6c3d44
出典データセット
uspto-grants-2005_09
特許番号
US06949542B2

反応ノート

読み込み中…