Phthalic Anhydride → 2-Pyrimidin-4-yl-indan-1,3-dione

HRID 49901

反応式

HRID 49901 の反応式
[C:1]1(=[O:11])[O:6][C:4](=O)[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[CH3:12][C:13]1[CH:18]=[CH:17][N:16]=[CH:15][N:14]=1>CO>[N:16]1[CH:17]=[CH:18][C:13]([CH:12]2[C:1](=[O:11])[C:2]3[C:3](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:4]2=[O:6])=[N:14][CH:15]=1

参加物

4

反応物 2

HCID 6811Phthalic AnhydrideHCID 189224-Methylpyrimidine

生成物 1

HCID 126190852-Pyrimidin-4-yl-indan-1,3-dione

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

7.87 g (53.1 mmol) phthalic acid anhydride and 22 ml (0.24 mol) 4-methylpyrimidine are stirred for 1 h at 140° C. and for 4 h at 21° C. The reaction mixture is then stirred with 15 ml methanol, filtered, and the residue washed with methanol. Further product is obtainable by evaporating the filtrate and stirring the residue with water: m.p.: 168-169° C.); Anal. calc.(C13H8N2O2) C, 69.64%; H, 3.60%; N, 12.49%. found C, 69.8%; H, 3.7%; N, 12.4%; FAB MS (M+H)+=225.

後処理

  1. filtrationfiltered
  2. washthe residue washed with methanol
  3. customby evaporating the filtrate

出典と根拠

ORDレコード
ord-370e9ebb6a7a4f78a9080c96b605ea60
出典データセット
uspto-grants-2004_03
特許番号
US06710047B2

関連ノート

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