Ethylenediamine → 4-(2-Imidazolin-2-YL)-7-methylchromane

HRID 499019ノート

反応式

HRID 499019 の反応式
CO[C:3]1[CH:12]=[C:11]2[C:6](C[CH2:8][CH2:9][CH:10]2[C:13]#[N:14])=[CH:5][C:4]=1[CH3:15].[CH2:16]([NH2:19])[CH2:17]N.C1(C)C=CC(S(O)(=O)=[O:27])=CC=1>>[NH:19]1[CH2:16][CH2:17][N:14]=[C:13]1[CH:10]1[C:11]2[C:6](=[CH:5][C:4]([CH3:15])=[CH:3][CH:12]=2)[O:27][CH2:8][CH2:9]1

参加物

4

反応物 3

HCID 3301EthylenediamineHCID 6101p-Toluenesulfonic acidHCID 675300557-Methoxy-6-methyl-1,2,3,4-tetrahydronaphthalenecarbonitrile

生成物 1

HCID 675308994-(2-Imidazolin-2-YL)-7-methylchromane

実験手順

This compound was prepared in a manner analogous to that of Step G of Example 1, by the reaction of 0.6 gram (0.003 mole) of 7-methylchromane-4-carbonitrile (iv) and 2 grams (0.008 mole) of the ethylenediamine salt of p-toluenesulfonic acid (prepared in Step F of Example 1). The reaction product was purified by column chromatography on Grade II basic alumina (3% water) using mixtures of methylene chloride and methanol as an eluant. The appropriate fractions of eluate were combined and concentrated under reduced pressure, yielding 0.25 gram of subject compound. The NMR spectrum was consistent with the proposed structure.

後処理

  1. customThis compound was prepared in a manner analogous to that of Step G of Example 1
  2. customThe reaction product was purified by column chromatography on Grade II basic alumina (3% water)
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-43fc559c00264666b1228adeb298978e
出典データセット
uspto-grants-2010_08
特許番号
US07767667B2

反応ノート

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