Trifluoroacetic acid → 3-Methylazetidine-3-carbonitrile; trifluoroacetic acid

HRID 499075ノート

反応式

HRID 499075 の反応式
[C:1]([C:3]1([CH3:14])[CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1)#[N:2].[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[CH3:14][C:3]1([C:1]#[N:2])[CH2:6][NH:5][CH2:4]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 56971684tert-Butyl 3-cyano-3-methylazetidine-1-carboxylate

生成物 1

HCID 673862343-Methylazetidine-3-carbonitrile; trifluoroacetic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl 3-cyano-3-methylazetidine-1-carboxylate (30.0 mg, 0.15 mmol) in dichloromethane (5 ml) was added trifluoroacetic acid (2 ml) and the solution stirred at room temperature for 1 hr. The reaction was concentrated and dried under vacuum to give a viscous oil which was used crude in subsequent chemistry.

後処理

  1. concentrationThe reaction was concentrated
  2. customdried under vacuum
  3. customto give a viscous oil which

出典と根拠

ORDレコード
ord-d2868ab612694b18a9a36e847c53f85a
出典データセット
uspto-grants-2010_08
特許番号
US07767672B2

反応ノート

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