Piperazine → 3-Piperazin-1-yl-6-pyridin-2-ylpyridazine

HRID 499152ノート

反応式

HRID 499152 の反応式
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:6][CH:7]=1.[NH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>C(#N)C>[N:14]1([C:2]2[N:3]=[N:4][C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=3)=[CH:6][CH:7]=2)[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1

参加物

4

反応物 2

HCID 4837PiperazineHCID 64179603-Chloro-6-(pyridin-2-yl)pyridazine

生成物 1

HCID 336763413-Piperazin-1-yl-6-pyridin-2-ylpyridazine収率 77%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of 3-chloro-6-pyridin-2-ylpyridazine (0.250 g, 1.300 mmol) in acetonitrile (15 mL) was added piperazine (0.335 g, 3.900 mmol) and the mixture was stirred at reflux for 4 hours. The solvent was removed in vacuo. The residue was purified by column chromatography to afford the title compound in 77% yield (0.240 g).

後処理

  1. temperatureat reflux for 4 hours
  2. customThe solvent was removed in vacuo
  3. customThe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-419a398f3bc241d981e2e48ebc57225b
出典データセット
uspto-grants-2010_08
特許番号
US07767677B2

反応ノート

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