Iodoethane → 1-Ethyl-3-{6-[4-(2-trifluoromethylbenzoyl)-piperazin-1-YL]pyridazin-3-YL}-imidazolidin-2-one
反応式
I[CH2:2][CH3:3].[F:4][C:5]([F:33])([F:32])[C:6]1[CH:31]=[CH:30][CH:29]=[CH:28][C:7]=1[C:8]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[N:21]=[N:20][C:19]([N:22]3[CH2:26][CH2:25][NH:24][C:23]3=[O:27])=[CH:18][CH:17]=2)[CH2:12][CH2:11]1)=[O:9]>>[CH2:2]([N:24]1[CH2:25][CH2:26][N:22]([C:19]2[N:20]=[N:21][C:16]([N:13]3[CH2:12][CH2:11][N:10]([C:8](=[O:9])[C:7]4[CH:28]=[CH:29][CH:30]=[CH:31][C:6]=4[C:5]([F:4])([F:32])[F:33])[CH2:15][CH2:14]3)=[CH:17][CH:18]=2)[C:23]1=[O:27])[CH3:3]参加物
3
実験手順
Following the procedure as described in Example 2, making variations only as required to use 1-iodoethane in place of 1-iodo-3-methylbutane to react with 1-{6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazin-3-yl}imidazolidin-2-one, the title compound was obtained as a white solid in 72% yield (0.061 g). 1H NMR (300 MHz, CDCl3) δ 8.44 (d, J=9.9 Hz, 1H), 7.72-7.69 (m, 1H), 7.62-7.49 (m, 2H), 7.34-7.32 (m, 1H), 6.99 (d, J=9.9 Hz, 1H), 4.08 (t, J=7.8 Hz, 2H), 3.95-3.84 (m, 2H), 3.6 (t, J=5.1 Hz, 2H), 3.52-3.47 (m, 4H), 3.38-3.25 (m, 4H), 1.16 (t, J=6.9 Hz, 3H). 13C NMR (75 MHz, CDCl3) δ167.4, 156.9, 156.8, 150.03, 134.4, 132.2, 129.3, 127.4, 127.2, 127.02, 126.8, 126.6, 126.2, 125.4, 121.7, 119.9, 118.1, 116.2, 46.4, 45.9, 45.5, 41.2, 41.1, 41.03, 38.3, 12.5. MS (ES+) m/z 449 (M+1).