Hydrochloric Acid → 1-(2-Methoxy-5-propylphenyl)ethanone

HRID 499220

反応式

HRID 499220 の反応式
[Al+3].[Cl-].[Cl-].[Cl-].[C:5](Cl)([CH3:7])=[O:6].[CH2:9]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)[CH2:10][CH3:11].Cl>ClCCl>[CH3:19][O:18][C:15]1[CH:16]=[CH:17][C:12]([CH2:9][CH2:10][CH3:11])=[CH:13][C:14]=1[C:5](=[O:6])[CH3:7]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 77024-PropylanisoleHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 684544751-(2-Methoxy-5-propylphenyl)ethanone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
-10 °C

実験手順

A suspension of 10.6 g of AlCl3 in 150 ml of dichloromethane is cooled to −10° C. 5.7 ml of AcCl and 6 g of 4-propylanisole are added. The medium is stirred at −10° C. for 30 min, and then poured into a beaker containing ice mixed with 35% HCl. After separation by settling out, the aqueous phase is extracted 3 times in dichloromethane, and the combined organic phases are washed with water and with a saturated NaCl solution, dried over MgSO4 and then evaporated, to give 7.86 g of a brown oil (quant.).

後処理

  1. additionpoured into a beaker
  2. additioncontaining ice
  3. customAfter separation
  4. extractionthe aqueous phase is extracted 3 times in dichloromethane
  5. washthe combined organic phases are washed with water and with a saturated NaCl solution
  6. dry with materialdried over MgSO4
  7. customevaporated

出典と根拠

ORDレコード
ord-ff7b12e1e5114d81b9ff79a24e6944c5
出典データセット
uspto-grants-2010_08
特許番号
US07767681B2

関連ノート

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