Trifluoroacetic acid → (1-Methylpiperidin-2-yl)piperazin-1-ylmethanone
反応式
C(O)(C(F)(F)F)=O.C(OC([N:15]1[CH2:20][CH2:19][N:18]([C:21]([CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][N:24]2[CH3:29])=[O:22])[CH2:17][CH2:16]1)=O)(C)(C)C>C(Cl)Cl>[CH3:29][N:24]1[CH2:25][CH2:26][CH2:27][CH2:28][CH:23]1[C:21]([N:18]1[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]1)=[O:22]参加物
4
実験手順
2 ml of TFA are added to a solution of 0.84 g of the compound obtained in step 5.3, in 2 ml of DCM. The medium is stirred at AT for 6 h. The medium is evaporated, taken up several times in DCM, and evaporated so as to entrain the TFA. The medium is taken up in DCM and then treated with a 10% NH4OH solution. The organic phase is dried over MgSO4 and then evaporated, to give 0.15 g of the expected product.
後処理
- customThe medium is evaporated
- customevaporated so as
- additiontreated with a 10% NH4OH solution
- dry with materialThe organic phase is dried over MgSO4
- customevaporated
出典と根拠
- ORDレコード
- ord-0834ac3fee5d42198a5a63a47cef7077
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07767681B2
反応ノート
読み込み中…