6-Chloropyridine-2-carbonitrile → 6-(Methylthio)picolinonitrile

HRID 499290ノート

反応式

HRID 499290 の反応式
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]#[N:9])[N:3]=1.[CH3:10][S-:11].[Na+]>O1CCCC1>[C:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([S:11][CH3:10])[N:3]=1)#[N:9]

参加物

4

反応物 2

HCID 1184246-Chloropyridine-2-carbonitrileHCID 4378561Sodium methanethiolate

生成物 1

HCID 229394456-(Methylthio)picolinonitrile収率 101.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
90 °C

実験手順

A mixture of 2-chloro-6-cyanopyridine (0.70 g, 5.0 mmol), sodium thiomethoxide (0.39 g, 5.5 mmol) and tetrahydrofuran (50 ml) was stirred at 90° C. for 18 hrs. The reaction mixture was concentrated under reduced pressure, combined with water and extracted with ethyl acetate. The extract was washed with saturated brine and dried, and the solvent was evaporated under reduced pressure to give the titled compound as an oil (0.76 g, 98%).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with saturated brine
  4. customdried
  5. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-ceb8354aad6f4c52b1aca7df984d5ca5
出典データセット
uspto-grants-2010_08
特許番号
US07767665B2

反応ノート

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