Pyridine-2-carbonitrile → 7-methoxy-2-(2-pyridyl)-4H-1,3-benzothiazine-4-one

HRID 499300ノート

反応式

HRID 499300 の反応式
[SH:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)#[N:14]>N1C=CC=CC=1>[CH3:12][O:11][C:9]1[CH:8]=[CH:7][C:3]2[C:4](=[O:6])[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[S:1][C:2]=2[CH:10]=1

参加物

4

反応物 2

HCID 7522Pyridine-2-carbonitrileHCID 139616424-Methoxy-2-sulfanylbenzoic acid

生成物 1

HCID 597501107-methoxy-2-(2-pyridyl)-4H-1,3-benzothiazine-4-one収率 47%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A mixture of 2-mercapto-4-methoxybenzoic acid (1.4 g, 7.9 mmol), 2-cyanopyridine (0.89 g, 8.5 mmol) and pyridine (10 ml) was refluxed for 10 hrs as described in Example 9. After cooling, the precipitated crystals were collected by filtration and recrystallized from hexane-tetrahydrofuran to give the titled compound (1.0 g, 47%) as crystals.

後処理

  1. temperaturewas refluxed for 10 hrs
  2. temperatureAfter cooling
  3. filtrationthe precipitated crystals were collected by filtration
  4. customrecrystallized from hexane-tetrahydrofuran

出典と根拠

ORDレコード
ord-5eecfc02d78b4f59b45d1416fb6018e4
出典データセット
uspto-grants-2010_08
特許番号
US07767665B2

反応ノート

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