m-Chloroperbenzoic acid → tert-Butyl 2-pyridinecarboxylate N-oxide
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8].ClC1C=CC=C(C(OO)=[O:22])C=1>C(OCC)(=O)C>[N+:1]1([O-:22])[C:2]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
4
実験手順
tert-Butyl 2-pyridinecarboxylate (14.0 g, 78 mmol) was dissolved in ethyl acetate (200 ml), and 3-chloroperbenzoic acid (ca. 77%, 26.2 g, 117 mmol) was added thereto. The reaction mixture was stirred at room temperature for 40 hrs. The solvent was evaporated under reduced pressure. The residue was subjected to a silica gel column chromatography and eluted with ethyl acetate-acetone (1:1, v/v) to give the titled compound (12.4 g, 81%).
後処理
- customThe solvent was evaporated under reduced pressure
- washeluted with ethyl acetate-acetone (1:1
出典と根拠
- ORDレコード
- ord-0c7151d8a4eb42b688206ea6a1b25aef
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07767665B2
反応ノート
読み込み中…