Tetrahydrofuran → 6-(Methylthio)nicotinonitrile

HRID 499418ノート

反応式

HRID 499418 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]#[N:9])=[CH:4][N:3]=1.[CH3:10][S-:11].[Na+].C1COCC1.C(OCC)(=O)C>O>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([S:11][CH3:10])=[N:3][CH:4]=1)#[N:9]

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 4378561Sodium methanethiolateHCID 51520946-Chloro-3-pyridinecarbonitrile

生成物 1

HCID 229395276-(Methylthio)nicotinonitrile収率 100%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-Chloro-5-cyanopyridine (2.10 g, 15.1 mmol) and sodium thiomethoxide (1.16 g, 16.5 mmol) were added to THF (30 ml). The reaction mixture was refluxed for 9 hrs and combined with ethyl acetate and water. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the titled compound (2.26 g, 100%) as pale yellow crystals.

後処理

  1. temperatureThe reaction mixture was refluxed for 9 hrs
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-87a4d9ad0796450d925b4650bea98971
出典データセット
uspto-grants-2010_08
特許番号
US07767665B2

反応ノート

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