HCID 22939293、化合物 → 3-[6-(7-Fluoro-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid

HRID 499431ノート

反応式

HRID 499431 の反応式
[F:1][C:2]1[CH:27]=[CH:26][C:5]2[C:6](=[O:25])[N:7]=[C:8]([C:10]3[N:15]=[C:14]([CH2:16][CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])[CH:13]=[CH:12][CH:11]=3)[S:9][C:4]=2[CH:3]=1>FC(F)(F)C(O)=O>[F:1][C:2]1[CH:27]=[CH:26][C:5]2[C:6](=[O:25])[N:7]=[C:8]([C:10]3[N:15]=[C:14]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])[CH:13]=[CH:12][CH:11]=3)[S:9][C:4]=2[CH:3]=1

参加物

3

反応物 1

HCID 22939293HCID 22939293、化合物

生成物 1

HCID 597504583-[6-(7-Fluoro-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid収率 100.1%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

反応条件

温度
0 °C

実験手順

tert-Butyl 3-[6-(7-fluoro-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propanoate (0.50 g, 1.3 mmol) was dissolved in trifluoroacetic acid (5 ml), and the mixture was stirred at 0° C. for 2 hrs. The solvent was evaporated, and the residue was crystallized from diethyl ether to give the titled compound (0.43 g, 99%) as white crystals.

後処理

  1. customThe solvent was evaporated
  2. customthe residue was crystallized from diethyl ether

出典と根拠

ORDレコード
ord-ca4f61d3f39244d99df8167fa3e00abc
出典データセット
uspto-grants-2010_08
特許番号
US07767665B2

反応ノート

読み込み中…