m-Chloroperbenzoic acid → 2-(1,3-Oxazol-5-yl)pyridine N-oxide

HRID 499453ノート

反応式

HRID 499453 の反応式
[O:1]1[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=2)=[CH:4][N:3]=[CH:2]1.ClC1C=CC=C(C(OO)=[O:20])C=1>C(OCC)(=O)C>[O:1]1[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][N+:7]=2[O-:20])=[CH:4][N:3]=[CH:2]1

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 7371945-(2-Pyridyl)oxazole

生成物 1

HCID 597502552-(1,3-Oxazol-5-yl)pyridine N-oxide収率 35.7%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

2-(1,3-Oxazol-5-yl)pyridine (2.8 g, 19 mmol) and 3-chloroperbenzoic acid (77%, 13.6 g, 58 mmol) were dissolved in ethyl acetate, and the mixture was stirred at room temperature for 6 days. The solvent was evaporated, and the residue was subjected to a silica gel column chromatography. The fractions eluted with methanol-ethyl acetate (1:4, v/v) were collected and concentrated to give the titled compound (1.1 g, 34%).

後処理

  1. customThe solvent was evaporated
  2. washThe fractions eluted with methanol-ethyl acetate (1:4, v/v)
  3. customwere collected
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-013b466719404f18a21568ba7f25a6af
出典データセット
uspto-grants-2010_08
特許番号
US07767665B2

反応ノート

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