m-Chloroperbenzoic acid → HCID 86628983、化合物

HRID 499483ノート

反応式

HRID 499483 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:3][CH:2]=1.ClC1C=CC=C(C(OO)=[O:25])C=1>C(OCC)(=O)C>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][NH+:9]([O-:25])[C:10](=[O:16])[O:11][C:12]([CH3:13])([CH3:15])[CH3:14])=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 12010540Tert-butyl N-[2-(pyridin-4-YL)ethyl]carbamate

生成物 1

HCID 86628983HCID 86628983、化合物収率 100.2%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

tert-Butyl 2-(4-pyridyl)ethylcarbamate (6.9 g, 31 mmol) and 3-chloroperbenzoic acid (77%, 9.1 g, 40 mmol) were dissolved in ethyl acetate (100 ml), and the mixture was stirred at room temperature for 3 hrs. The solvent was evaporated, and the residue was subjected to a silica gel column chromatography. The fractions eluted with methanol-ethyl acetate (1:3, v/v) were collected and concentrated to give the titled compound (7.4 g, 99%).

後処理

  1. customThe solvent was evaporated
  2. washThe fractions eluted with methanol-ethyl acetate (1:3
  3. customv/v) were collected
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-a1ba03e748824321b43ba591b4b693a6
出典データセット
uspto-grants-2010_08
特許番号
US07767665B2

反応ノート

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