Lithium Hydroxide → 2-Methoxy-5-(thiophene-3-yl)benzoic acid
反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Li+]>C1(C)C=CC=CC=1.C(O)C.O>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]参加物
4
実験手順
Methyl 2-Methoxy-5-(thiophene-3-yl)benzoate (124 mg) was dissolved in a solvent mixture of tetrahydrofuran/methanol/water (2/1/1, 3 ml). Lithium hydroxide (53 mg) was added to the obtained solution, and they were stirred overnight. The solvent was evaporated, and the residue was added to 3 N hydrochloric acid. The white solid thus precipitated was taken by the filtration as the title compound.
後処理
- customThe solvent was evaporated
- additionthe residue was added to 3 N hydrochloric acid
- customThe white solid thus precipitated
- filtrationwas taken by the filtration as the title compound
出典と根拠
- ORDレコード
- ord-482ac188de284002a6553410a0302fe4
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06710056B2
反応ノート
読み込み中…