Acetic Anhydride → 3-(2-Pyridyl)propyl acetate

HRID 499571

反応式

HRID 499571 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][CH2:9][OH:10].[C:11](OC(=O)C)(=[O:13])[CH3:12]>N1C=CC=CC=1>[C:11]([O:10][CH2:9][CH2:8][CH2:7][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)(=[O:13])[CH3:12]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 72922Pyripropanol

生成物 1

HCID 234486323-(2-Pyridyl)propyl acetate収率 99.4%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2-Pyridinepropanol (2.0 g, 14.6 mmol) was dissolved in pyridine (5 ml), and acetic anhydride (3.0 g, 29.2 mmol) was added thereto. The reaction mixture was stirred at room temperature for 2.5 hrs, and subjected to a silica gel (75 g) column chromatography. The fractions eluted with hexane-ethyl acetate (3:1, v/v) were collected and concentrated to give the titled compound (2.6 g, 99%).

後処理

  1. washThe fractions eluted with hexane-ethyl acetate (3:1
  2. customv/v) were collected
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-c448b787721b4073b3743c225cff8fc7
出典データセット
uspto-grants-2010_08
特許番号
US07767665B2

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