Ammonium formate → HCID 22939450、化合物

HRID 499588

反応式

HRID 499588 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[CH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14].C([O-])=O.[NH4+]>C(O)C.O.[C].[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14]

参加物

6

反応物 2

HCID 2723923Ammonium formateHCID 684573677-(2-Pyridyl)-6-heptenoic acid

生成物 1

HCID 22939450HCID 22939450、化合物収率 91.4%

試薬・触媒・溶媒 3

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

7-(2-Pyridyl)-6-heptenoic acid (0.97 g, 4.7 mmol) was dissolved in ethanol (15 ml), and 10% palladium-carbon (0.16 g) and a solution of ammonium formate (1.7 g, 27.0 mmol) in water (2 ml) were added thereto. The reaction mixture was refluxed for 2 hrs. Palladium-carbon was filtered off. The reaction mixture was combined with water, concentrated under reduced pressure to the half amount and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over magnesium sulfate. The solvent was concentrated under reduced pressure to give the titled compound (0.89 g, 91%).

後処理

  1. temperatureThe reaction mixture was refluxed for 2 hrs
  2. filtrationPalladium-carbon was filtered off
  3. concentrationconcentrated under reduced pressure to the half amount
  4. extractionextracted with ethyl acetate
  5. washThe organic layer was washed with saturated brine
  6. dry with materialdried over magnesium sulfate
  7. concentrationThe solvent was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-aa4057061bc8452ebfc384b864b0f52e
出典データセット
uspto-grants-2010_08
特許番号
US07767665B2

関連ノート

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