4-Methylmorpholine → Dextroamphetamine

HRID 500349

反応式

HRID 500349 の反応式
C1CCC(N=C=NC2CCCCC2)CC1.S(O)(O)(=O)=O.[NH2:21][CH:22]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH3:23].CN1CCOCC1>CN(C=O)C.O1CCOCC1.O>[CH3:23][C@H:22]([NH2:21])[CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

参加物

5

反応物 3

HCID 79724-MethylmorpholineHCID 10868DicyclohexylcarbodiimideHCID 222898Amphedrine

生成物 1

HCID 5826Dextroamphetamine

試薬・触媒・溶媒 1

HCID 86622776DMF dioxane water溶媒

実験手順

O-Acetyl-l-carnitine·Cl (1.000 g, 4.17 mmol) was dissolved in 12.5 mL of a mixture of DMF/dioxane/water (2:2:1). NHS (0.528 g, 4.59 mmol) and DCC (0.947 g, 4.59 mmol) were added and the mixture was stirred overnight at ambient temperature. Solvents were evaporated and the remaining residue was dried overnight in high vacuum. The crude succinimidyl ester intermediate was dissolved in 20 mL of anhydrous DMF. Amphetamine sulfate (0.700 g, 1.90 mmol) and NMM (0.92 mL, 8.34 mmol) were added and the mixture stirred overnight. Solvent was evaporated to dryness and the remaining residue was leached with IPA. Solvent was evaporated to yield Carn-d-amphetamine.

後処理

  1. customSolvents were evaporated
  2. customthe remaining residue was dried overnight in high vacuum
  3. dissolutionThe crude succinimidyl ester intermediate was dissolved in 20 mL of anhydrous DMF
  4. stirringthe mixture stirred overnight
  5. customSolvent was evaporated to dryness
  6. customSolvent was evaporated

出典と根拠

ORDレコード
ord-684be369b7ea4f9bb6157c8fc9ed90a1
出典データセット
uspto-grants-2010_08
特許番号
US07772222B2

関連ノート

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