1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine

HRID 500489

反応式

HRID 500489 の反応式
[N:1]1([CH2:7][CH2:8][OH:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>C(Cl)Cl>[OH:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][N:4]([C:10](=[O:12])[CH3:11])[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 7918Acetic Anhydride

生成物 1

HCID 47396291-Acetyl-4-(2-hydroxyethyl)piperazine収率 65%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 2-(1-piperazinyl)-1-ethanol (6.5 g 0.05 mol) in DCM (5 mL) was treated with acetic acid anhydride (5.1 g, 0.05 mol), added dropwise. During addition, the reaction temperature rose from 22 to 60° C. The reaction mixture was evaporated several times with toluene to yield 5.6 g (65%) of the sub-title compound.

後処理

  1. additionadded dropwise
  2. additionDuring addition
  3. customrose from 22 to 60° C
  4. customThe reaction mixture was evaporated several times with toluene

出典と根拠

ORDレコード
ord-d4d753808d88424382dcf7134625b815
出典データセット
uspto-grants-2010_08
特許番号
US07772229B2

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