化工社化工社 化学情報印刷レポート · 研究参考用
1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Acetyl-4-(2-hydroxyethyl)piperazine | HCID 4739629 | 65% |
反応手順
A solution of 2-(1-piperazinyl)-1-ethanol (6.5 g 0.05 mol) in DCM (5 mL) was treated with acetic acid anhydride (5.1 g, 0.05 mol), added dropwise. During addition, the reaction temperature rose from 22 to 60° C. The reaction mixture was evaporated several times with toluene to yield 5.6 g (65%) of the sub-title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07772229B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-d4d753808d88424382dcf7134625b815 |
| 出典メモ | uspto-grants-2010_08 |