Sodium borohydride → HCID 57528604、化合物

HRID 500525ノート

反応式

HRID 500525 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][N:11]=[C:10]([C:13](=[O:15])[CH3:14])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][N:11]=[C:10]([CH:13]([OH:15])[CH3:14])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 467019251-[5-(3-Chlorophenyl)-1,2-oxazol-3-yl]ethan-1-one

生成物 1

HCID 57528604HCID 57528604、化合物収率 109.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

In a screw cap vial equipped with stir bar added the title compound of Example 6.1 (100 mg, 0.45 mmol), sodium borohydride (34 mg, 0.90 mmol) and methanol (3 mL). The resulting mixture was stirred at room temperature for 3 h. The reaction was quenched with water (30 mL) and brine (30 mL), extracted with dichloromethane (3 times 30 mL). The combined organic phase was dried (sodium sulfate), filtered and concentrated, in vacuo to isolate the title compound as a white solid (110 mg).

後処理

  1. customIn a screw cap vial
  2. customequipped
  3. stirringThe resulting mixture was stirred at room temperature for 3 h
  4. customThe reaction was quenched with water (30 mL) and brine (30 mL)
  5. extractionextracted with dichloromethane (3 times 30 mL)
  6. dry with materialThe combined organic phase was dried (sodium sulfate)
  7. filtrationfiltered
  8. concentrationconcentrated, in vacuo

出典と根拠

ORDレコード
ord-38058b5b35264816b507ccc78975b40c
出典データセット
uspto-grants-2010_08
特許番号
US07772235B2

反応ノート

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