Hydrazine hydrate (1:1) → 2-Methoxyisonicotinohydrazide

HRID 500543ノート

反応式

HRID 500543 の反応式
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][N:7]=[C:6]([O:10][CH3:11])[CH:5]=1.O.[NH2:14][NH2:15]>C(O)C>[CH3:11][O:10][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][N:7]=1)[C:3]([NH:14][NH2:15])=[O:2]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 14223465Methyl 2-methoxyisonicotinate

生成物 1

HCID 3225512-Methoxyisonicotinohydrazide収率 80.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
75 °C

実験手順

2-Methoxy-isonicotinic acid methyl ester (23.0 g, 137 mmol) and hydrazine hydrate (8.95 g, 178 mmol) were dissolved in ethanol and stirred at 75° C. for 12 hours. The reaction mixture was concentrated and the remaining solid was tritiated in hexanes/ether (80:20), filtered and dried to afford the title compound as a solid (18.4 g, 80%).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. filtrationfiltered
  3. customdried

出典と根拠

ORDレコード
ord-7a2aeb8ffa114dd899881945ec8d3c9d
出典データセット
uspto-grants-2010_08
特許番号
US07772235B2

反応ノート

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