HCID 24851818、化合物 → HCID 24853176、化合物

HRID 500555ノート

反応式

HRID 500555 の反応式
C([O:8][C:9]1[CH:14]=[C:13]([C:15]2[N:19]([CH3:20])[C:18]([O:21][CH:22]([C:24]3[CH:28]=[C:27]([C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([Cl:35])[CH:30]=4)[O:26][N:25]=3)[CH3:23])=[N:17][N:16]=2)[CH:12]=[CH:11][N:10]=1)C1C=CC=CC=1>C(O)C.[Pd].ClCCl>[Cl:35][C:31]1[CH:30]=[C:29]([C:27]2[O:26][N:25]=[C:24]([CH:22]([O:21][C:18]3[N:19]([CH3:20])[C:15]([C:13]4[CH:12]=[CH:11][NH:10][C:9](=[O:8])[CH:14]=4)=[N:16][N:17]=3)[CH3:23])[CH:28]=2)[CH:34]=[CH:33][CH:32]=1

参加物

5

反応物 1

HCID 24851818HCID 24851818、化合物

生成物 1

HCID 24853176HCID 24853176、化合物収率 38%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 6344Dichloromethane溶媒

実験手順

The title compound of example 35.1 (125 mg, 0.256 mmol) was stirred in ethanol (2 mL). Palladium on carbon (10%, 50 mg) was added and the reaction was stirred under hydrogen (balloon pressure) overnight. The reaction mixture was then diluted with dichloromethane and filtered to remove the palladium catalyst. The filtrate was concentrated, then chromatographed in 10% methanol in ethyl acetate to yield the desired product (38.5 mg, 38%).

後処理

  1. filtrationfiltered
  2. customto remove the palladium catalyst
  3. concentrationThe filtrate was concentrated
  4. customchromatographed in 10% methanol in ethyl acetate

出典と根拠

ORDレコード
ord-a93f41b8699045c7999178beb229ede2
出典データセット
uspto-grants-2010_08
特許番号
US07772235B2

反応ノート

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