2-Chloroaniline → 5-Bromo-2-(2-chlorophenylamino)-3,4-difluorobenzoic acid

温度

-78 °C

To a solution of i-Pr2NH (25.0 mL, 178 mmol) in THF (200 mL) at 0° C. was added n-BuLi (71.0 mL, 178 mmol, 2.5 M solution in hexanes). After stirring for 15 minutes, this solution was cooled to −78° C. 2-Chloroaniline (12.7 mL, 118 mmol) was added. After vigorous stirring for 10 minutes, a solution of 5-bromo-2,3,4-trifluorobenzoic acid (14.95 g, 58.63 mmol) in THF (30 mL) was added. The dry-ice bath was removed, and the reaction mixture was stirred for 2 hours at room temperature. The mixture was concentrated, treated with 10% aqueous HCl (120 mL), extracted with EtOAc, dried over MgSO4, filtered, and concentrated to give the crude solid which was triturated with boiling CH2Cl2 (125 mL). The yellow solids were filtered, and dried in vacuo to give the desired product (17.4 g, 82%).

1. stirringAfter vigorous stirring for 10 minutes
2. customThe dry-ice bath was removed
3. stirringthe reaction mixture was stirred for 2 hours at room temperature
4. concentrationThe mixture was concentrated
5. additiontreated with 10% aqueous HCl (120 mL)
6. extractionextracted with EtOAc
7. dry with materialdried over MgSO4
8. filtrationfiltered
9. concentrationconcentrated
10. customto give the crude solid which
11. customwas triturated with boiling CH2Cl2 (125 mL)
12. filtrationThe yellow solids were filtered
13. customdried in vacuo

ORDレコード

ord-763cfd38f53343b4988c556c53be055a

出典データセット

uspto-grants-2010_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07772234B2