Potassium Carbonate → 1-Benzoyl-3-(3,4-dichlorophenyl)-3-[3-[4-phenyl-4-(pyrrolidin-1-ylcarbonyl)piperid-1-yl]propyl]perhydroazepine hydrochloride hemihydrate

HRID 50069

反応式

HRID 50069 の反応式
[C:1]1([C:7]2([C:13]([N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:14])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:20].C(N([C:26]1([C:58]2[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=2)[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][CH2:34][C:35]2([C:50]3[CH:55]=[CH:54][C:53]([Cl:56])=[C:52]([Cl:57])[CH:51]=3)[CH2:41][CH2:40][CH2:39][CH2:38][N:37]([C:42](=[O:49])[C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)[CH2:36]2)[CH2:28][CH2:27]1)C)(=O)C.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.C(#N)C>[OH2:14].[ClH:56].[C:42]([N:37]1[CH2:38][CH2:39][CH2:40][CH2:41][C:35]([C:50]2[CH:55]=[CH:54][C:53]([Cl:56])=[C:52]([Cl:57])[CH:51]=2)([CH2:34][CH2:33][CH2:32][N:10]2[CH2:11][CH2:12][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)([C:13]([N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:14])[CH2:8][CH2:9]2)[CH2:36]1)(=[O:49])[C:43]1[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=1.[C:42]([N:37]1[CH2:38][CH2:39][CH2:40][CH2:41][C:35]([CH2:34][CH2:33][CH2:32][N:29]2[CH2:28][CH2:27][C:26]([C:13]([N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:14])([C:58]3[CH:59]=[CH:60][CH:61]=[CH:62][CH:63]=3)[CH2:31][CH2:30]2)([C:50]2[CH:55]=[CH:54][C:53]([Cl:56])=[C:52]([Cl:57])[CH:51]=2)[CH2:36]1)(=[O:49])[C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1.[ClH:20]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 30194854-Phenyl-4-(pyrrolidin-1-ylcarbonyl)piperidineHCID 227417463-[3-[4-(Acetyl-N-methylamino)-4-phenylpiperid-1-yl]propyl]-1-benzoyl-3-(3,4-dichlorophenyl)perhydroazepine hydrochloride

生成物 1

HCID 1317216571-Benzoyl-3-(3,4-dichlorophenyl)-3-[3-[4-phenyl-4-(pyrrolidin-1-ylcarbonyl)piperid-1-yl]propyl]perhydroazepine hydrochloride hemihydrate収率 32.3%

試薬・触媒・溶媒 1

HCID 21891449acetonitrile N,N-dimethylformamide溶媒

実験手順

This compound is prepared by the procedure described in step D of EXAMPLE 13, starting from 0.96 g of 4-phenyl-4-(pyrrolidin-1-ylcarbonyl)-piperidine, 1.5 g of the compound obtained in step C of EXAMPLE 13 and 1.5 g of K2CO3 in 10 ml of a DMF/acetonitrile mixture (50/50; v/v). This gives 0.34 g of the expected product, m.p.=135° C.

後処理

  1. customThis compound is prepared by the procedure

出典と根拠

ORDレコード
ord-6ecf102744834b1ebe9597e3897c58fa
出典データセット
uspto-grants-2004_03
特許番号
US06710042B2

関連ノート

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