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Potassium Carbonate → 1-Benzoyl-3-(3,4-dichlorophenyl)-3-[3-[4-phenyl-4-(pyrrolidin-1-ylcarbonyl)piperid-1-yl]propyl]perhydroazepine hydrochloride hemihydrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Phenyl-4-(pyrrolidin-1-ylcarbonyl)piperidine | HCID 3019485 | — |
| 反応物 | 3-[3-[4-(Acetyl-N-methylamino)-4-phenylpiperid-1-yl]propyl]-1-benzoyl-3-(3,4-dichlorophenyl)perhydroazepine hydrochloride | HCID 22741746 | — |
| 溶媒 | acetonitrile N,N-dimethylformamide | HCID 21891449 | — |
| 生成物 | 1-Benzoyl-3-(3,4-dichlorophenyl)-3-[3-[4-phenyl-4-(pyrrolidin-1-ylcarbonyl)piperid-1-yl]propyl]perhydroazepine hydrochloride hemihydrate | HCID 131721657 | 32.3% |
反応手順
This compound is prepared by the procedure described in step D of EXAMPLE 13, starting from 0.96 g of 4-phenyl-4-(pyrrolidin-1-ylcarbonyl)-piperidine, 1.5 g of the compound obtained in step C of EXAMPLE 13 and 1.5 g of K2CO3 in 10 ml of a DMF/acetonitrile mixture (50/50; v/v). This gives 0.34 g of the expected product, m.p.=135° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06710042B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-6ecf102744834b1ebe9597e3897c58fa |
| 出典メモ | uspto-grants-2004_03 |