HRID50069

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID3019485

未命名化合物

结构：CC(=O)N(C)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCCN(C(=O)c3ccccc3)C2)CC1.Cl

HCID22741746

未命名化合物

PRODUCTS

生成物

结构：Cl.Cl.O.O=C(c1ccccc1)N1CCCCC(CCCN2CCC(C(=O)N3CCCC3)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1.O=C(c1ccccc1)N1CCCCC(CCCN2CCC(C(=O)N3CCCC3)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1

HCID131721657

未命名化合物

收率 32.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21891449

未命名化合物

PROCEDURE

实验过程

This compound is prepared by the procedure described in step D of EXAMPLE 13, starting from 0.96 g of 4-phenyl-4-(pyrrolidin-1-ylcarbonyl)-piperidine, 1.5 g of the compound obtained in step C of EXAMPLE 13 and 1.5 g of K2CO3 in 10 ml of a DMF/acetonitrile mixture (50/50; v/v). This gives 0.34 g of the expected product, m.p.=135° C.

WORKUP

后处理

customThis compound is prepared by the procedure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6ecf102744834b1ebe9597e3897c58fa
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06710042B2
来源说明: uspto-grants-2004_03

反应 SMILES

[C:1]1([C:7]2([C:13]([N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:14])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:20].C(N([C:26]1([C:58]2[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=2)[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][CH2:34][C:35]2([C:50]3[CH:55]=[CH:54][C:53]([Cl:56])=[C:52]([Cl:57])[CH:51]=3)[CH2:41][CH2:40][CH2:39][CH2:38][N:37]([C:42](=[O:49])[C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)[CH2:36]2)[CH2:28][CH2:27]1)C)(=O)C.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.C(#N)C>[OH2:14].[ClH:56].[C:42]([N:37]1[CH2:38][CH2:39][CH2:40][CH2:41][C:35]([C:50]2[CH:55]=[CH:54][C:53]([Cl:56])=[C:52]([Cl:57])[CH:51]=2)([CH2:34][CH2:33][CH2:32][N:10]2[CH2:11][CH2:12][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)([C:13]([N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:14])[CH2:8][CH2:9]2)[CH2:36]1)(=[O:49])[C:43]1[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=1.[C:42]([N:37]1[CH2:38][CH2:39][CH2:40][CH2:41][C:35]([CH2:34][CH2:33][CH2:32][N:29]2[CH2:28][CH2:27][C:26]([C:13]([N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:14])([C:58]3[CH:59]=[CH:60][CH:61]=[CH:62][CH:63]=3)[CH2:31][CH2:30]2)([C:50]2[CH:55]=[CH:54][C:53]([Cl:56])=[C:52]([Cl:57])[CH:51]=2)[CH2:36]1)(=[O:49])[C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1.[ClH:20]