3-(4-Phenylphenyl)prop-2-enoic acid → 5-[(R)-2-(2-{4-[4-(2-amino-2-methyl-propoxy)-phenylamino]-phenyl}-ethylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one Di-(4-phenylcinnamate)

HRID 500981

反応式

HRID 500981 の反応式
[NH2:1][C:2]([CH3:37])([CH3:36])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][NH:20][CH2:21][C@@H:22]([C:24]3[CH:33]=[CH:32][C:31]([OH:34])=[C:30]4[C:25]=3[CH:26]=[CH:27][C:28](=[O:35])[NH:29]4)[OH:23])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1.[C:38]1([C:44]2[CH:54]=[CH:53][C:47]([CH:48]=[CH:49][C:50]([OH:52])=[O:51])=[CH:46][CH:45]=2)[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1>O1CCCC1>[C:38]1([C:44]2[CH:45]=[CH:46][C:47]([CH:48]=[CH:49][C:50]([OH:52])=[O:51])=[CH:53][CH:54]=2)[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1.[C:38]1([C:44]2[CH:45]=[CH:46][C:47]([CH:48]=[CH:49][C:50]([OH:52])=[O:51])=[CH:53][CH:54]=2)[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1.[NH2:1][C:2]([CH3:37])([CH3:36])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([CH2:18][CH2:19][NH:20][CH2:21][C@@H:22]([C:24]3[CH:33]=[CH:32][C:31]([OH:34])=[C:30]4[C:25]=3[CH:26]=[CH:27][C:28](=[O:35])[NH:29]4)[OH:23])=[CH:16][CH:17]=2)=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 254923-(4-Phenylphenyl)prop-2-enoic acidHCID 11169365HCID 11169365、化合物

生成物 1

HCID 866073395-[(R)-2-(2-{4-[4-(2-amino-2-methyl-propoxy)-phenylamino]-phenyl}-ethylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one Di-(4-phenylcinnamate)

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

5-[(R)-2-(2-{4-[4-(2-amino-2-methyl-propoxy)-phenylamino]-phenyl}-ethylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (0.108 g) was slurried in aqueous tetrahydrofuran (1:1 THF:H2O, 1.2 mL). 4-Phenylcinnamic acid (0.049) was added to the stirred mixture at room temperature and spontaneous crystallisation occurred. The mixture was stirred for over 1 hour and then filtered. The filtered solid was washed with aqueous tetrahydrofuran (1:1 THF:H2O, 2×0.2 mL). Having been left to sit at ambient conditions for several hours, the wet solid was dried overnight at 60° C. in vacuo to give the title compound.

後処理

  1. customspontaneous crystallisation
  2. filtrationfiltered
  3. washThe filtered solid was washed with aqueous tetrahydrofuran (1:1 THF:H2O, 2×0.2 mL)
  4. waitHaving been left
  5. waitto sit at ambient conditions for several hours
  6. customthe wet solid was dried overnight at 60° C. in vacuo

出典と根拠

ORDレコード
ord-da0e03e77aaf403b87f4250448654ea5
出典データセット
uspto-grants-2010_08
特許番号
US07772250B2

関連ノート

読み込み中…