Sodium Hydroxide → HCID 22024679、化合物

HRID 501007ノート

反応式

HRID 501007 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([NH:7][CH:8]([CH2:11][CH3:12])[CH2:9][OH:10])=[N:3][CH:2]=1.[Br:13]Br.[OH-].[Na+]>C(O)(=O)C>[Br:13][C:5]1[C:4]([NH:7][CH:8]([CH2:11][CH3:12])[CH2:9][OH:10])=[N:3][CH:2]=[N:1][CH:6]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 24408BromineHCID 220243971-Butanol, 2-(4-pyrimidinylamino)-

生成物 1

HCID 22024679HCID 22024679、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

2-(4-Pyrimidinylamino)-1-butanol (4.2 g) was dissolved in acetic acid (42 mL), and bromine (1.5 mL) was added dropwise at a normal temperature. After stirred for 1 day at the same temperature, the solution was neutralized with a 5N aqueous sodium hydroxide solution and extracted with ethyl acetate, and the solvent was evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1.1) to give the title compound (4.4 g) as white crystals.

後処理

  1. extractionextracted with ethyl acetate
  2. customthe solvent was evaporated
  3. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1.1)

出典と根拠

ORDレコード
ord-ce9896d298fa4e62bba5fbfba8c67826
出典データセット
uspto-grants-2010_08
特許番号
US07772249B2

反応ノート

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