Thionyl Chloride → HCID 22024658、化合物

HRID 501008ノート

反応式

HRID 501008 の反応式
[Br:1][C:2]1[C:3]([NH:8][CH:9]([CH2:12][CH3:13])[CH2:10]O)=[N:4][CH:5]=[N:6][CH:7]=1.S(Cl)(Cl)=O>C1(C)C(C)=CC=CC=1>[Br:1][C:2]1[C:3]2[N:4]([CH2:10][CH:9]([CH2:12][CH3:13])[N:8]=2)[CH:5]=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 22024679HCID 22024679、化合物

生成物 1

HCID 22024658HCID 22024658、化合物収率 98.1%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

反応条件

温度
100 °C

実験手順

2-[(5-Bromo-4-pyrimidinyl)amino]-1-butanol (3.3 g) was dissolved in xylene (27 mL), then thionyl chloride (4.9 mL) was added thereto, and the mixture was heated under stirring at 100° C. for 1 day. The precipitated crystals were collected by filtration and suspended in a 1M aqueous sodium carbonate solution. This mixture was extracted with dichloromethane to give the crude title compound (3.0 g) as an orange oil. This title compound was used in the next reaction without purification.

後処理

  1. temperaturethe mixture was heated
  2. filtrationThe precipitated crystals were collected by filtration
  3. extractionThis mixture was extracted with dichloromethane

出典と根拠

ORDレコード
ord-281fe9257f52469ab646f0b24a9f47fc
出典データセット
uspto-grants-2010_08
特許番号
US07772249B2

反応ノート

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