Bromine → Phenacyl bromide

HRID 501268

反応式

HRID 501268 の反応式
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7](OC2C=CC=CC=2)=[CH:6][CH:5]=1)=[O:3].[Br:17]Br>>[Br:17][CH2:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3]

参加物

3

反応物 2

HCID 24408BromineHCID 2367834'-Phenoxyacetophenone

生成物 1

HCID 6259Phenacyl bromide

実験手順

4-Phenoxyacetophenone was brominated with bromine according to Method A to provide the desired α-bromoacetophenone, which was condensed with 2-amino-1,3,4,-thiadiazole-5-sulfonamide according to method C, to provide compound 87 as an off white solid. 1H NMR (200 MHz, DMSO-d6) δ 8.82 (s, 1H), 8.71 (s, 2H), 7.90 (d, J=7.9 Hz, 2H), 7.40 (t, J=7.3 Hz, 2H), 7.07 (t, J=7.3 Hz, 1H), 7.08-7.03 (m, 6H).

出典と根拠

ORDレコード
ord-8bfbfe3959c148d9bed9f6cb3ab2818e
出典データセット
uspto-grants-2010_08
特許番号
US07772260B2

関連ノート

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