Hydrogen Bromide → HCID 23112415、化合物

反応式

COC([N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[C:12]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:13]=3[S:14][CH:15]=2)[CH2:7][CH2:6]1)=O.[BrH:24]>>[BrH:24].[F:23][C:20]([F:21])([F:22])[C:17]1[CH:18]=[CH:19][C:12]2[C:11]([CH:8]3[CH2:7][CH2:6][NH:5][CH2:10][CH2:9]3)=[CH:15][S:14][C:13]=2[CH:16]=1

参加物

反応物 2

HCID 260Hydrogen Bromide

HCID 58817563HCID 58817563、化合物

生成物 1

HCID 23112415HCID 23112415、化合物収率 94%

実験手順

A mixture of 4-(6-trifluoromethyl-benzo[b]thiophen-3-yl)-piperidine-1-carboxylic acid methyl ester (3.1 g, 9.0 mmol) in HBr (45 mL, 30% in acetic acid) was stirred at room temperature for 20 hours when the volatiles were removed in vacuo. The residue was washed with EtOAc and the product was collected by filtration yielding 3.09 g (94%) of the desired product as a white solid.

後処理

customwere removed in vacuo
washThe residue was washed with EtOAc
filtrationthe product was collected by filtration

出典と根拠

ORDレコード: ord-0413b12ce85545ef9b5212370cdc3d78
出典データセット: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07772252B2

反応ノート

読み込み中…

参加物