1-Methyl-4-nitro-1H-benzimidazole → 4-Amino-1-methylbenzimidazole
反応式
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-])=O)[C:5]=2[N:4]=[CH:3]1>CCO.[Pd]>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([NH2:11])[C:5]=2[N:4]=[CH:3]1参加物
4
実験手順
A suspension of 1-methyl-4-nitro-1H-benzimidazole [2.1 g, 12 mmol, prepared as described in Viktor Milata et. al., Org. Prep. Proced. Int. 25 (6), 703-704 (1993)] and 5% Pd/C (0.21 g) in EtOH (40 mL) was vigorously stirred under an atmosphere of hydrogen at rt overnight. The reaction mixture was filtered and the filtrate concentrated under reduced pressure to afford the title compound (1.65 g).
後処理
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-fd9fca2332024759bfd75888ee1080ae
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07772267B2
反応ノート
読み込み中…