Hydrochloric Acid → 4-Formyl-3-methoxybenzoic acid

HRID 501812

反応式

HRID 501812 の反応式
[CH:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9]C)=[O:8])=[CH:5][C:4]=1[O:13][CH3:14])=[O:2].O.Cl>CO.[OH-].[Na+]>[CH:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[O:13][CH3:14])=[O:2]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 10631650Methyl 4-formyl-3-methoxybenzoate

生成物 1

HCID 189595314-Formyl-3-methoxybenzoic acid収率 93.4%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

1.72 g of methyl 4-formyl-3-methoxybenzoate was dissolved in 8.6 mL of methanol, to which 2.6 mL of a 20% aqueous solution of sodium hydroxide was added at room temperature, and this solution was stirred for one hour at the same temperature. The reaction mixture, to which water was added, was adjusted to pH 2 with 6M hydrochloric acid, and resultant precipitate was filtered out therefrom and washed with water to yield 1.49 g of 4-formyl-3-methoxybenzoic acid as light yellow solid.

後処理

  1. additionwas added at room temperature
  2. filtrationwas filtered out therefrom and
  3. washwashed with water

出典と根拠

ORDレコード
ord-f300ada960e6404c8c73162ae3ae4977
出典データセット
uspto-grants-2010_08
特許番号
US07772285B2

関連ノート

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