Hydrochloric Acid → 4-Hydroxytetrahydro-2H-thiopyran 1,1-dioxide
反応式
[O:1]=[S:2]1(=[O:9])[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.[BH4-].[Na+].Cl>O>[O:1]=[S:2]1(=[O:9])[CH2:7][CH2:6][CH:5]([OH:8])[CH2:4][CH2:3]1参加物
5
実験手順
To 1,1-dioxo-tetrahydrothiopyran-4-one (6.3 g, 36 mmol) in H2O (55 mL) was added, in portions, sodium borohydride (720 mg, 18.9 mmol). The reaction mixture was stirred at room temperature for 30 minutes and then the pH was adjusted to 4 with aq. HCl. The reaction mixture was concentrated and suspended in acetone and filtered. The filtrate was concentrated and triturated with ether/hexane to provide 1,1-dioxo-tetrahydrothiopyran-4-ol (5.63 g, 90%) as a white solid.
後処理
- concentrationThe reaction mixture was concentrated
- filtrationfiltered
- concentrationThe filtrate was concentrated
- customtriturated with ether/hexane
出典と根拠
- ORDレコード
- ord-1d34609765ef4ddba2330123799f8f0d
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07772271B2
反応ノート
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