HCID 68459332、化合物 → HCID 58706348、化合物
反応式
[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([CH2:10][OH:11])[CH:7]=[CH:6][C:5]=1[C:12]1[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=1)[CH3:2]>ClCCl.O=[Mn]=O>[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([CH:10]=[O:11])[CH:7]=[CH:6][C:5]=1[C:12]1[CH:17]=[CH:16][C:15]([C:18]([F:19])([F:20])[F:21])=[CH:14][CH:13]=1)[CH3:2]参加物
4
実験手順
The above prepared (2-ethoxy-4′-trifluoromethyl-biphenyl-4-yl)-methanol (0.359 g, 1.21 mmol) was dissolved in 12 ml of dichloromethane and treated with MnO2 (2.11 g, 20 eq.). After vigorous stirring for 8 h at ambient temperature, the reaction mixture was filtered over a pad of Celite, rinsed generously with dichloromethane, and evaporated to dryness to leave, after flash chromatography (silica gel, hexane/AcOEt=9/1) 0.372 g of the title aldehyde as yellow solid.