Diethyl Ether → 2-Benzofuran-3-yl-ethanol

HRID 502503ノート

反応式

HRID 502503 の反応式
CO[C:3](=O)[CH2:4][C:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[O:7][CH:6]=1.[Li].CC[O:18]CC>>[CH:6]1[O:7][C:8]([CH:13]([OH:18])[CH3:12])=[C:9]2[CH:10]=[CH:11][CH:3]=[CH:4][C:5]=12

参加物

4

反応物 3

HCID 3283Diethyl Ether2 回HCID 3028194LithiumHCID 10976279Methyl Benzofuran-3-acetate

生成物 1

HCID 684582562-Benzofuran-3-yl-ethanol

実験手順

A solution of benzofuran-3-yl-acetic acid methyl ester (4.0 g, 21 mmol) in 25 ml of ether was added dropwise at RT to a suspension of lithium alanate (1.61 g, 59.5 mmol) in 35 ml of ether, and stirring was then carried out for 30 minutes. Excess alanate was then hydrolysed with ethanol, the mixture was suction-filtered over Kieselguhr, and the solvent was removed in vacuo. The product was obtained in the form of a yellowish oil in a yield of 3.0 g (89%).

後処理

  1. filtrationhydrolysed with ethanol, the mixture was suction-filtered over Kieselguhr
  2. customthe solvent was removed in vacuo
  3. customThe product was obtained in the form of a yellowish oil in a yield of 3.0 g (89%)

出典と根拠

ORDレコード
ord-59bad4e82581494b96c626227b667a12
出典データセット
uspto-grants-2010_08
特許番号
US07776848B2

反応ノート

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