Trifluoroacetic acid → Trifluoroacetate

HRID 502672ノート

反応式

HRID 502672 の反応式
C(OC(=O)[NH:7][CH2:8][CH:9]1[CH2:13][CH2:12][CH2:11][S:10]1)(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>C(Cl)Cl>[S:10]1[CH2:11][CH2:12][CH2:13][CH:9]1[CH2:8][NH2:7].[F:15][C:16]([F:21])([F:20])[C:17]([O-:19])=[O:18]

参加物

5

反応物 2

HCID 6422Trifluoroacetic acid2 回HCID 68460638HCID 68460638、化合物

生成物 2

HCID 84468Trifluoroacetate収率 83%HCID 15629560Tetrahydro-2-thiophenemethanamine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 2-[(N-tbutoxycarbonlylamino)methyl]-tetrahydrothiophene 222 (500 mg, 2.3 mmol) in DCM (25 mL) was treated with trifluoroacetic acid (10 mL). The mixture was stirred at rt for 1 h before the DCM and excess TFA were removed under reduced pressure. The oily residue was triturated with diethyl ether to afford 223 as its trifluoroacetate salt (440 mg, 1.9 mmol, 83%) as an off-white solid, which was used without further purification.

後処理

  1. customwere removed under reduced pressure
  2. customThe oily residue was triturated with diethyl ether

出典と根拠

ORDレコード
ord-74f7f6cb35b34a97b55b6f19c66b4494
出典データセット
uspto-grants-2010_08
特許番号
US07776867B2

反応ノート

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