Water → 1-Bromo-4-iodo-2-(phenoxymethyl)benzene

HRID 502846ノート

反応式

HRID 502846 の反応式
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:8][C:9]1[CH:14]=[CH:13][C:12]([I:15])=[CH:11][C:10]=1[CH2:16]Cl.[Na+].[I-].O>[OH-].[K+].CC(C)=O>[Br:8][C:9]1[CH:14]=[CH:13][C:12]([I:15])=[CH:11][C:10]=1[CH2:16][O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

7

反応物 4

HCID 962WaterHCID 996PhenolHCID 5238Sodium IodideHCID 593463281-Bromo-2-(chloromethyl)-4-iodobenzene

生成物 1

HCID 593463231-Bromo-4-iodo-2-(phenoxymethyl)benzene

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 14797Potassium Hydroxide溶媒

反応条件

温度
50 °C

実験手順

Phenol (13 g) dissolved in 4 M KOH solution (60 mL) is added to 4-bromo-3-chloromethyl-1-iodo-benzene (41.0 g) dissolved in acetone (50 mL). NaI (0.5 g) is added and the resulting mixture is stirred at 50° C. overnight. Then, water is added and the resulting mixture is extracted with ethyl acetate. The combined extracts are dried and the solvent is evaporated under reduced pressure. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 19:1).

後処理

  1. extractionthe resulting mixture is extracted with ethyl acetate
  2. customThe combined extracts are dried
  3. customthe solvent is evaporated under reduced pressure
  4. customThe residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 19:1)

出典と根拠

ORDレコード
ord-0258ce7110954712b9aac5f9dcfc8bde
出典データセット
uspto-grants-2010_08
特許番号
US07776830B2

反応ノート

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