Ethanol → 2-Methyl-2-(2-thienyl)propanohydrazide

HRID 502947ノート

反応式

HRID 502947 の反応式
O.[NH2:2][NH2:3].C(O)C.[CH3:7][C:8]([C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)([CH3:14])[C:9](OCC)=[O:10].C(OCC)(=O)C>O>[CH3:7][C:8]([C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)([CH3:14])[C:9]([NH:2][NH2:3])=[O:10]

参加物

6

反応物 4

HCID 702EthanolHCID 8857Ethyl AcetateHCID 24654Hydrazine hydrate (1:1)HCID 21099804Ethyl 2-methyl-2-(thiophen-2-yl)propanoate

生成物 1

HCID 684672282-Methyl-2-(2-thienyl)propanohydrazide

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

Hydrazine monohydrate (2.6 ml) was added to an ethanol (10 ml) solution of ethyl 2-methyl-2-(2-thienyl)propanoate (530 mg), followed by stirring at 70° C. for 48 hours. After the reaction solution and ethyl acetate were added to water, the organic layer was separated. Furthermore, the organic layer washed with saturated brine and, after drying over anhydrous sodium sulfate and filtration, the solvent was removed by evaporation under reduced pressure to obtain 447 mg of 2-methyl-2-(2-thienyl)propanohydrazide (colorless oil).

後処理

  1. customthe organic layer was separated
  2. washFurthermore, the organic layer washed with saturated brine
  3. dry with materialafter drying over anhydrous sodium sulfate and filtration
  4. customthe solvent was removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-f2d9600b8fef4ae08d1d12d2e70eb7b7
出典データセット
uspto-grants-2010_08
特許番号
US07776897B2

反応ノート

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